TO ESTIMATE AND COMPARE THE SERUM ADA LEVELS IN TYPE 2 DIABETES PATIENTS WITH AGE/SEX MATCHED NON-DIABETIC CONTROLS AND IT’S CORRELATION WITH THE DEVELOPMENT OF MICRO AND MACROVASCULAR COMPLICATIONS

Abstract

Background: ADA is an enzyme of purine metabolism catalysing irreversible deamination of adenosine to inosine & 2-deoxyadenosine to 2-deoxyinosine respectively. Inosine & 2-deoxyinosine are converted to hypoxanthine, xanthine & finally to uric acid. ADA is considered as a good marker of the cell-mediated immune response. Studies have shown that in patients with T2DM, the level of ADA is higher than that of non-diabetics.  

Objective: To estimate and compare the serum ADA levels in type 2 Diabetes patients with age/sex-matched non-diabetic controls and it’s a correlation with the development of micro and macrovascular complications.

Study-Design: Case-Control study

Material & Methods: The quantitative determination of ADA concentration was done by Colorimetric method.

Results: The mean ±SD serum ADA levels in diabetic cases was found to be 38.7±16.02, which was higher than that in the control group, 28.9 ±6.39 (p <0.001).

Conclusions: ADA is the marker of oxidative stress and has a role in insulin resistance. Therefore, routine screening of serum ADA should be carried out in persons with impaired glucose tolerance to assess the level of burden of oxidative stress in the body and hence the risk of development of diabetes.